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KMID : 0359020100400030175
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Korean Journal of Gastrointestinal Endoscopy
2010 Volume.40 No. 3 p.175 ~ p.180
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Two Cases of Gastric Marginal Zone B Cell Lymphoma Treated with a Single Agent Chemotherapy
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Bae Young Seok
Lee Kwang-Jae
Kim Dong-Wan
Hong Jun-Ho
Yoon Jung-Bin
Bae Sang-Hoon
Lee Jin-Sook
Song Chul-Soo
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Abstract
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Gastric marginal zone B cell lymphoma of the MALT type (MALT lymphoma) is usually accompanied by a Helicobacter pylori (H. pylori) infection. Most gastric MALT lymphomas regress after the eradication of H. pylori. Therefore, H. pylori eradication therapy is an effective first-line treatment for gastric MALT lymphoma. A second-line treatment for patients who fail to respond to eradication therapy, including radiotherapy and chemotherapy, produces a good response and survival rate. We encountered 2 cases of H. pylori eradication-resistant gastric MALT lymphoma, which were treated with cyclophosphamide monotherapy. A complete response was obtained in both cases after a treatment duration of 3 months and remission continued for 15 and 18 months, respectively. Treatment-related toxicity was mild. Oral monochemotherapy might be an alternative, effective and safe treatment modality for patients with gastric MALT lymphoma who are resistant to H. pylori eradication therapy.
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KEYWORD
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Stomach, Marginal zone, MALT, Cyclophosphamide
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